Risk of Dementia in Patients with Parkinson's Disease, Epilepsy, and Severe Head Trauma: A Register-based Follow-up Study
Identifieur interne : 002227 ( Main/Exploration ); précédent : 002226; suivant : 002228Risk of Dementia in Patients with Parkinson's Disease, Epilepsy, and Severe Head Trauma: A Register-based Follow-up Study
Auteurs : Monique M. B. Breteler [Pays-Bas] ; Regina R. M. De Groot [Pays-Bas] ; Leo K. J. Van Romunde [Pays-Bas] ; Albert Hofman [Pays-Bas]Source :
- American Journal of Epidemiology [ 0002-9262 ] ; 1995-12-15.
Abstract
The authors investigated the risk of developing dementia for persons aged 50–75 years who suffered from Parkinson's disease, epilepsy, or severe head trauma. They compared the risk in this patient group with the risk in a reference group in a follow-up study based on the linked databases of three Dutch nationwide morbidity registers over the years 1980–1989. The overall relative risk of developing dementia within 8 years in patients with Parkinson's disease who were initially free of dementia was 3.0 (95% confidence interval (Cl) 2.9–3.1). Risk was especially increased in younger Parkinson's disease patients (relative risk (RR) = 13.2, 95% Cl 6.2–28.6). For patients with epilepsy, the overall relative risk was 1.5 (95% Cl 1.4–1.7). Severe head trauma was not associated with an increased risk of dementia (RR = 1.0, 95% Cl 0.9–1.1). These findings suggest that Parkinson's disease is an important risk factor for dementia, with a particularly high risk in young patients with Parkinson's disease. Patients with epilepsy may bear a moderately increased risk of developing dementia. This study does not support earlier findings in retrospective case-control studies of an increased risk of dementia in head trauma patients.
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DOI: 10.1093/oxfordjournals.aje.a117597
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B." last="Breteler">Monique M. B. Breteler</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Erasmus University Medical School Rotterdam</wicri:regionArea><wicri:noRegion>Erasmus University Medical School Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="De Groot, Regina R M" sort="De Groot, Regina R M" uniqKey="De Groot R" first="Regina R. M." last="De Groot">Regina R. M. De Groot</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>SIG Informatiecentrum voor de Gezondheidszorg Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Van Romunde, Leo K J" sort="Van Romunde, Leo K J" uniqKey="Van Romunde L" first="Leo K. J." last="Van Romunde">Leo K. J. 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They compared the risk in this patient group with the risk in a reference group in a follow-up study based on the linked databases of three Dutch nationwide morbidity registers over the years 1980–1989. The overall relative risk of developing dementia within 8 years in patients with Parkinson's disease who were initially free of dementia was 3.0 (95% confidence interval (Cl) 2.9–3.1). Risk was especially increased in younger Parkinson's disease patients (relative risk (RR) = 13.2, 95% Cl 6.2–28.6). For patients with epilepsy, the overall relative risk was 1.5 (95% Cl 1.4–1.7). Severe head trauma was not associated with an increased risk of dementia (RR = 1.0, 95% Cl 0.9–1.1). These findings suggest that Parkinson's disease is an important risk factor for dementia, with a particularly high risk in young patients with Parkinson's disease. Patients with epilepsy may bear a moderately increased risk of developing dementia. This study does not support earlier findings in retrospective case-control studies of an increased risk of dementia in head trauma patients.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name></noRegion><name sortKey="De Groot, Regina R M" sort="De Groot, Regina R M" uniqKey="De Groot R" first="Regina R. M." last="De Groot">Regina R. M. De Groot</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Van Romunde, Leo K J" sort="Van Romunde, Leo K J" uniqKey="Van Romunde L" first="Leo K. J." last="Van Romunde">Leo K. J. Van Romunde</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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